CCR2Ly-6C monocytes are crucial for the effector phase of autoimmunity in the central nervous system
نویسندگان
چکیده
1 Department of Neuropathology, University of Freiburg, Freiburg, Germany 2 Department of Internal Medicine, University of Regensburg, Regensburg, Germany 3 Department of Neuropathology, Georg-August University, Göttingen, Germany 4 Department of Neurology, Georg-August University, Göttingen, Germany 5 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA 6 Department of Radiation Oncology, Georg-August University, Göttingen, Germany 7 Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité-Universitätsmedizin Berlin, Berlin, Germany
منابع مشابه
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ.
During central nervous system autoimmunity, interactions between infiltrating immune cells and brain-resident cells are critical for disease progression and ultimately organ damage. Here, we demonstrate that local cross-talk between invading autoreactive T cells and auto-antigen-presenting myeloid cells within the central nervous system results in myeloid cell activation, which is crucial for d...
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